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Sunday, July 26, 2020 | History

1 edition of Human variability in susceptibility to toxic chemicals. found in the catalog.

Human variability in susceptibility to toxic chemicals.

Human variability in susceptibility to toxic chemicals.

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Published by U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office in Cincinnati, OH .
Written in English

    Subjects:
  • Pollution -- Environmental aspects -- United States,
  • Environmental impact analysis -- United States

  • Edition Notes

    ContributionsUnited States. Environmental Protection Agency. Environmental Criteria and Assessment Office
    The Physical Object
    Pagination[2] p. ;
    ID Numbers
    Open LibraryOL14892370M

      Certain microbiomes or microbiota may become associated with different health outcomes, such as resistance or susceptibility to exposure to certain toxic chemicals, the ability to recover following a chemical-induced injury, the presence of disease-associated phenotypes, and the effectiveness of immune by: 2. Hattis D, Banati P, and Goble R () Distributions of individual susceptibility among humans for toxic effects: How much protection does the traditional tenfold factor provide for what fraction of which kinds of chemicals and effects?

      In the absence of direct human evidence that there are sex-related differences in age-specific susceptibility as substantial as those indicated in Tables 9 we recommend that risk assessors give most emphasis to the total population projections (both sexes combined) in evaluating the potential significance of early-life by: • A comparison of the dose-response curves for two or more different chemicals – administered to the same type of test animal – can be used to determine the relative toxicity of the chemicals. • The LD50 for chemical A is less than the LD50 for chemical B. Therefore, chemical File Size: 1MB.

    We screened 81 human lymphoblast cell lines with chemicals at 12 different concentrations and assessed the toxic response using different endpoints (cell death and caspase production). We evaluated the toxic responses to a panel of chemicals observed in lymphoblast cell lines, and compared them to other toxic responses seen with different Author: Nour Abdo.   Introduction. The response of individual humans to hazardous exposures can vary significantly and this variability is thought to underlie individual predispositions to to diseases and/or sensitivity to toxic exposures ().While basic biological mechanisms pertinent to humans are being studied in laboratory animals, the variability of human responses to chemicals, including drugs and Author: Daria Filonov, Raymond Tice, Ruiyan Luo, Chad Grotegut, Michael J. Van Kanegan, John W. Ludlow, Dora.


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Human variability in susceptibility to toxic chemicals Download PDF EPUB FB2

This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community Human variability in susceptibility to toxic chemicals.

book others are expected to characterize human health risks associated with exposure to by: 9. Get this from a library. Human variability in susceptibility to toxic chemicals. I, Noncarcinogens. [United States.

Environmental Protection Agency. Environmental Criteria and Assessment Office.;]. More recently, a review of human variability in different routes of metabolism of environmental chemicals suggests a range greater than fold in individual susceptibility to some chemicals (Dorne et al.

In general, improvements in risk assessment are expected as more research is done to determine the range of allele frequencies and the. and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to by: 9.

Book Description. and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals.

Susceptibility as a Function of the Source-to-Outcome Continuum and Biological Variability. The “source-to-outcome continuum” [U.S. Environmental Protection Agency (EPA) ; NRC ] is a conceptual framework for human health risk assessment of environmental chemicals in which changes in the sources of chemicals in the environment are further propagated within the individual through a Cited by: "And for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals.

Human Variability and Susceptibility to Trichloroethylene Article Literature Review in Environmental Health Perspectives Suppl 2(Suppl 2) June with 13 Reads. With completion of the sequencing effort of the Human Genome Project, new opportunities have arisen to more fully characterize the genetic contribu- tions to variation in human susceptibility to toxic effects of pharmaceuticals and other chemicals.

Hattis, D. Banati, P., Goble, R., and Burmaster, D. "Human Interindividual Variability in Parameters Related to Health Risks, Risk Analysis, Vol. 19, pp.Hattis, D., Banati, P., and Goble, R. "Distributions of Individual Susceptibility Among Humans for Toxic Effects--For What Fraction of Which Kinds of Chemicals and Effects Does.

Free Online Library: Addressing human variability in next-generation human health risk assessments of environmental chemicals.(Review, Report) by "Environmental Health Perspectives"; Health, general Environmental issues Cells Models Cells (Biology) Chemicals Analysis Health aspects Health risk assessment Research Usage Risk assessment.

Addressing Human Variability in Next-Generation Human Health Risk Assessments of Environmental Available via license: Public Domain Mark Content may be subject to copyright. Human variability in susceptibility to toxic chemicals: a preliminary analysis of pharmacokinetic data from normal volunteers Technical Report Hattis, D.

; Erdreich, L. ; Ballew, M. The tenfold uncertainty factor traditionally used to guard against human interindividual differences in susceptibility to toxicity is not based on human observations.

CONCLUSION: In view of these problems, we recommend caution in the use of HVD modeling as a general approach to estimating low-dose risks from human exposures to toxic chemicals.

KEY WORDS: dose--response model, human variability distribution, log-normal distribution, low-dose risk, risk assessment, threshold distribution. Visit to get more information about this book, to buy it in print, or to download it as a free PDF.

Originally published inthis book is designed so that those familiar with the use of expert judgment can quickly find the material appropriate for their advanced background.

Grounds of the Immaterial. Niels van Dijk — A Conflict-Based Approach to Intellectual Rights. Individuals differ widely in their susceptibility to the adverse effects of occupational and environmental chemicals (28, ).

During the past several decades considerable effort has been directed to studying the occurrence and biochemical bases of individual differences in susceptibility to toxic substances (28, 32, 36, 37, 50, 61 Cited by: 1.

Introduction. The response of individual humans to hazardous exposures can vary significantly and this variability is thought to underlie individual predispositions to to diseases and/or sensitivity to toxic exposures ().While basic biological mechanisms pertinent to humans are being studied in laboratory animals, the variability of human responses to chemicals, including drugs and Author: Daria Filonov, Raymond Tice, Ruiyan Luo, Chad Grotegut, Michael J.

Van Kanegan, John W. Ludlow, Dora. Haitis, L. Erdreich and M. Ballew, Human Variability to Toxic Chemicals—A Preliminary Analysis of Pharmokinetic Data from Normal Volunteers, Risk Analysis – ().

CrossRef Google ScholarCited by: 3. A procedure known as human biomonitoring measures the size of human exposures to chemicals, their biochemical effects, and individual susceptibility.

This chapter summarizes biomarkers currently used for carcinogen biomonitoring and highlights their value and limitations, restricting the examples of exposures to those chemicals classified in. Abstract. Response to environmental chemicals can vary widely among individuals and between population groups.

In human health risk assessment, data on susceptibility can be utilized by deriving risk levels based on a study of a susceptible population and/or an uncertainty factor may be applied to account for the lack of information about susceptibility.Risk Assessment in the Federal Government: Managing the Process ("The Red Book") Detailed steps of hazard identification, dose-response assessment, exposure analysis, and characterization of risks provides consistent framework for risk assessment across agencies: research feeds into risk assessments/ crucial data uncertainty drives research.

Alternative Strategies for Quantification of Non-Cancer Health Risks, Utilizing Human Information on Interindividual Variability Goble R.

Distributions of individual susceptibility among humans for toxic effects: how much protection does the traditional tenfold factor provide for what fraction of which kinds of chemicals and effects.