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Sunday, August 9, 2020 | History

4 edition of Ions, Cell Proliferation, and Cancer found in the catalog.

Ions, Cell Proliferation, and Cancer

Alton Boynton

Ions, Cell Proliferation, and Cancer

by Alton Boynton

  • 221 Want to read
  • 1 Currently reading

Published by Academic Pr .
Written in English


The Physical Object
Number of Pages564
ID Numbers
Open LibraryOL7325856M
ISBN 100121230503
ISBN 109780121230500

  Cancer researchers, at both the basic cell-biology and the clinical level, have rightfully focused on the control of cell proliferation for decades. Underlying much of this research is the assumption that cells in multicellular organisms are primarily subject to positive growth regulation, i.e., these cells are normally not proliferating but Reviews: 3. Thus, hijacking of potassium ion channel function by cancer cells has the potential to affect cell proliferation, cell survival, migration, and differentiation. Interestingly, however, although most potassium channels have been found to be overexpressed in cancer, Kv is one of only two potassium channels that is downregulated.

Title:Chickpea Lectin Inhibits Human Breast Cancer Cell Proliferation and Induces Apoptosis Through Cell Cycle Arrest VOLUME: 25 ISSUE: 5 Author(s):Neha Gupta, Prakash S. Bisen and Sameer Suresh Bhagyawant* Affiliation:School of Studies in Biotechnology, Jiwaji University, Gwalior, , School of Studies in Biotechnology, Jiwaji University, Gwalior, , School of Studies in. The control of cell proliferation involves diverse signaling pathways, growth factors, and receptors. The involvement of ion channels in this process is supported by a wealth of experimental evidence with mechanisms not always well understood. However, the emerging roles ion channels play in such cellular processes are related to changes in Ca2+ signaling, stressing its importance in.

Bioenergetics of Human Cancer Cells and Normal Cells during Proliferation and Differentiation Nina A. Mikirova1* cancer cell mitochondria have different properties than normal cell mitochondria, consistent with the potential via buildup of hydrogen ions, increases emission at . Cancer cells can both acquire the ability to secrete PDGF and to express PDGF receptor, creating a self-stimulatory loop. Growth factor receptors: transmembrane proteins that signal intracellular molecules to carry out cell proliferation when bound by a growth factor. Growth factor receptors in cancer cells can either be overexpressed or.


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Ions, Cell Proliferation, and Cancer by Alton Boynton Download PDF EPUB FB2

This book provides an understanding of the control of cell proliferation and the deregulated proliferation of cancer cells. Organized into three sections encompassing 32 chapters, this book begins with an overview of the important role that ions in animal cells play in a variety of fundamental processes associated with essential cell Edition: 1.

This book provides an understanding of the control of cell proliferation and the deregulated proliferation of cancer cells. Organized into three sections encompassing 32 chapters, this book begins with an overview of the important role that ions in Ions cells play in a variety of fundamental processes associated with essential cell functions.

Ions, Cell Proliferation, and Cancer [Paperback] [] (Author) Alton L. Boynton on *FREE* shipping on qualifying offers. Ions, Cell Proliferation, and Cancer. ISBN: OCLC Number: Notes: "Proceedings of the Symposium on Ions, Cell Proliferation, and Cancer, sponsored by the National Cancer Institutes, the W.

Alton Jones Cell Science Center, and the National Research Council of Canada, held at the W. Alton Jones Cell Science Center, Lake Placid, New York, July"--Page [ii]. However, cancer cells evade cell death, tipping the balance to an overabundance of cell number.

Therefore, overcoming this resistance to cell death is a decisive factor in the treatment of cancer. Ion channels play a critical role in cancer in regards to cell proliferation, malignant angiogenesis, migration and by: Cell proliferation in normal cells is a and Cancer book, well synchronized event that is stringently regulated by a number of ions, molecules and proteins associated with the cell cycle machinery including Ca ++, ATP, cyclins, cyclin dependent kinases and many other cell cycle regulators [11,12].A cell cycle can be distinguished into phases (), namely, the G0 phase, comprised mainly of the non.

After the early wavering steps tracing back to at least the ’s (Cone, ; Binggeli and Cameron, ), the Cell Proliferation of ion transport in cell proliferation and neoplasia is on its way to become a mature research field (Arcangeli at al., ). Wide evidence is now available about the regulatory roles exerted by ion channels and transporters on the cell cycle phases (Becchetti, ) and.

However, cancer cells evade cell death, tipping the balance to an overabundance of cell number. Therefore, overcoming this resistance to cell death is a decisive factor in the treatment of cancer. Ion channels play a critical role in cancer in regards to cell proliferation, malignant angiogenesis, migration and.

Hoffmann, E. Ion channels involved in cell volume regulation: effects on migration, proliferation, and programmed cell death in non adherent EAT cells and adherent ELA cells. Cell. Killing cancer cells by cytotoxic T lymphocytes (CTL) and by natural killer (NK) cells is of vital importance.

Cancer cell proliferation and apoptosis depend on the intracellular Ca 2 + concentration, and the expression of numerous ion channels with the ability to control intracellular Ca 2 + concentrations has been correlated with cancer.

A rise of intracellular Ca 2 + concentrations is also. Functional assays in vitro. To assess the effects of treatment on proliferation, cells were seeded after treatment into 96 transparent well plates at a density of 5 × 10 3 cells per well.

The. Changes of the electrical charges across the surface cell membrane are absolutely necessary to maintain cellular homeostasis in physiological as well as in pathological conditions. The opening of ion channels alter the charge distribution across the surface membrane as they allow the diffusion of ions such as K+, Ca++, Cl−, Na+.

Traditionally, voltage-gated ion channels (VGIC) are known to. signalling in promoting tumour cell proliferation and migration. 12 Intriguingly, copper‐specific chelators or inhibitors of ATOX1 and CCS have been demonstrated to be capable of suppressing the proliferation of several cancer cells.

9,12,13 Tetrathiomolybdate (TM), a well‐tolerated copper chelator, is shown to inhibit tumour angiogen ‐. Rozengurt E () Monovalent ion fluxes, cyclic nucleotides and the stimulation of DNA synthesis in quiescent cells. In: Boynton AL, McKeehan WL, Whitfield JF (eds) Ions, cell proliferation and cancer.

Academic Press, London, New York, pp – Google Scholar. Genre/Form: Congress Electronic books Conference papers and proceedings Congresses Congrès: Additional Physical Format: Print version: Symposium on Ions, Cell Proliferation, and Cancer ( W. Alton Jones Cell Science Center).

Ca2+ activated Cl− channels (TMEM16A; ANO1) support cell proliferation and cancer growth. Expression of TMEM16A is strongly enhanced in different types of malignomas.

In contrast, TMEM16F (ANO6) operates as a Ca2+ activated chloride/nonselective ion channel and scrambles membrane phospholipids to expose phosphatidylserine at the cell surface.

Both phospholipid scrambling and cell. This book provides an understanding of mechanisms that control animal cell proliferation. Organized into five parts encompassing 17 chapters, this volume begins with an overview of the efforts to elucidate he genetic alterations that lead normal cells to become cancer cells, which have been aided considerably by the investigation of acute.

Three studies have shown that it is, however, effective against breast (2), bladder (3) and prostate cancer (4) cell lines. In researchers from Nottingham University (Biochemical and Biophysical Research Communications) found that vanilloids bind to proteins in the cancer cell mitochondria to trigger apoptosis, or cell death, in lung cancer cells without harming surrounding healthy cells.

Normal cells are subject to signals that regulate their proliferation and behaviour. All cancers disrupt normal controls of cell proliferation & for each cell there is a finite number of ways this disruption can occur.

Cancer cells develop a degree of autonomy from external regulatory signals that are responsible for normal cellular homeostasis. Note that concentrations can change by more than an order of magnitude depending on cell type and physiological and environmental conditions such as the medium osmolarity or external pH.

Na+ concentrations are especially hard to measure due to trapping and sticking of ions to cells. Most Mg2+ ions are bound to ATP and other cellular components. The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A and its possible mechanism on the VEGF/VEGFR signal pathway were investigated.

All cancers won’t exhibit each one of these traits, but these are the traits responsible for the insidious, mysterious nature of many cancer cells. These abnormal cell processes are initiated as a result of genetic alterations that lead to abnormal cell proliferation.

The cancer cells will then typically form a lump called a neoplasm.Finally, having overcome normal controls on cell birth and cell death, an aspiring cancer cell faces two new challenges: it must overcome replicative senescence and become immortal and it must obtain adequate supplies of nutrients and oxygen to maintain this high rate of proliferation.